CL075 CL075 (3M002) is a thiazoloquinolone derivative that stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12 [1]. CL075 seems also to induce the secretion of IFN-α through TLR7 but to a lesser extend. It induces the activation of NF-κB at 0.4 µM (0.1 µg/ml) in TLR8-transfected HEK293 cells, and ~ 10 times more CL075 is required to activate NF-κB in TLR7-transfected HEK293 cells. Specificity: human TLR7/8 and mouse TLR7 agonist Working Concentration: • 0.1 - 5 μg/ml CL075 for human TLR8 and mouse TLR7 • 0.5 - 5 μg/ml CL075 for human TLR7 Endotoxin level: EndoFit™ (<0.001 EU/µg) Solubility: 1 mg/ml in water Formula: C13H13N3S Molecular weight: 243.33