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Celastrol
NF-κB inhibitor
Celastrol, a quinone methide triterpene isolated from the Chinese medicinal plant Tripterygium wilfordii, is known for its antitumor and anti-inflammatory properties but its mode of action and spectrum of cellular targets are poorly understood. Celastrol was recently found to be a potent inhibitor of the heat-shock protein Hsp90 inducing the disruption of protein-protein interactions of Hsp90 and its co-chaperones [1,2]. Furthermore, it was shown to act as an effective inhibitor of the transcription factor NF-κB potentiating the apoptosis induced by TNF-α and chemotherapeutic agents and inhibiting invasion [3].
Working concentration: 2.5-10 μM
Purity: >98%
Endotoxin levels: <0.125 EU/mg
CAS number: 34157-83-0
Molecular weight: 450.6
Solubility: approximately 10 mg/ml in ethanol and DMSO; 20 mg/ml in DMF
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