|
Anti-Slo1, clone L6/60
Species Reactivity Key Applications Host Format Antibody Type
R, M IHC, WB, ICC Mouse Purified Monoclonal Antibody
Description:
Anti-Slo1 Antibody, clone L6/60
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes S9-S10 segments of Slo1.
Molecular Weight:
~100 kDa observed
Epitope:
S9-S10 segments
Immunogen:
Recombinant protein corresponding to the S9-S10 segments of mouse Slo1.
Clone:
L6/60
Isotype:
IgG2aκ
Background Information:
Slo1 (Calcium-activated potassium channel subunit alpha-1) may not only be activated by membrane depolarization but may also be by an increase in cytosolic Ca2+. The concentration of cytosolic Mg2+ also activates this potassium channel. Found to play a part in the repolarization of the membrane potential due to the fact that it diminishes the excitatory voltage in the cell.
View All »
Species Reactivity:
Rat
Mouse
Species Reactivity Note:
Demonstrated to react with rat. Predicted to react with mouse based on immunogen design.
Application Notes:
Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Slo1 in rat cerebellum tissue.
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Misonou, H., et al. (2006). J Comp Neurol. 496(3):289–302.)
View All »
Control:
Rat brain membrane tissue lysate
Quality Assurance:
Evaluated by Western Blot in rat brain membrane tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Slo1 on 10 µg of rat brain membrane tissue lysate.
Purification Method:
Protein G
Presentation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q08460
Entrez Gene Number:
NP_034740
Gene Symbol:
SLO1
KCa1.1
SAKCA
SLO
k(VCA)alpha
mSLO1
BKTM
MaxiK
KCNMA1
hSlo
KCNMA3
Slo1
View All »
Alternate Names:
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Slo homolog
stretch-activated Kca channel
Maxi K channel
Drosophila slowpoke-like
Calcium-activated potassium channel, subfamily M subunit alpha-1
Slowpoke homolog
BK channel
calcium-activated potassium channel subunit alpha-1
BKCA alpha
BKCA alpha subunit
K(VCA)alpha
SLO-ALPHA
Slo-alpha
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunohistochemistry
Western Blotting
Immunocytochemistry
UniProt Summary:
FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitab |