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Anti-PSD95, clone K28/43
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REFERENCES
Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
Qiong Wang,Steven H Green (2011) The Journal of neuroscience : the official journal of the Society for Neuroscience.31
Species Reactivity Key Applications Host Format Antibody Type
R, M, H IHC, WB, ICC Mouse Purified Monoclonal Antibody
Description:
Anti-PSD95 Antibody, clone K28/43
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Molecular Weight:
~95 kDa observed.
Immunogen:
Recombinant protein corresponding to human PSD95.
Clone:
K28/43
Isotype:
IgG2aκ
Background Information:
PSD95 (postsynaptic density 95) represent a class of anchoring proteins which serve to localize various neuronal ion channels to post-synaptic densities. PSD95 and related proteins contain PDZ domains, which interact with NMDA receptors and voltage-gated K+ channels via a ET/SXV motif in the cytoplasmic carboxyl terminus of the receptor channels.
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Species Reactivity:
Rat
Mouse
Human
Species Reactivity Note:
Demonstrated to react with rat. Predicted to react with mouse based on 100% sequence homology. Predicted to react with human based on immunogen design.
Application Notes:
Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected PSD95 in rat cortex tissue.
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Maeda, T., et al. (2005). Invest. Ophthalmol. Vis. Sci. 46(11):4320-4327.)
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Control:
Rat brain tissue lysate
Quality Assurance:
Evaluated by Western Blot in rat brain tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PSD95 on 10 µg of rat brain tissue lysate.
Purification Method:
Protein G Purified
Presentation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P78352
Entrez Gene Number:
NP_001356
Gene Symbol:
PSD-95
PSD95
SAP-90
SAP90
Alternate Names:
Postsynaptic density protein 95
Synapse-associated protein 90
Tax interaction protein 15
discs large homolog 4
discs, large homolog 4 (Drosophila)
post-synaptic density protein 95
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunohistochemistry
Western Blotting
Immunocytochemistry
Entrez Gene Summary:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
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UniProt Summary:
FUNCTION: Interacts with the cytoplasm |