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英文名: Chloramphenicol , D(-)-threo-2-Dichloroacetamido-1-(p-nitrophenyl)-1,3-propanediol
性 状: 针状或细长的片状结晶。真空时升华。25℃时溶解度：水中2.5mg/ml、丙二醇中150.8mg/ml。易溶于甲醇、乙醇、丁醇、乙酸乙酯、丙酮，微溶于乙醚，不溶于苯、石油醚、植物油。水溶液呈中性。中性或酸性溶液受热时稳定。熔点150.5～151.5℃。比旋光度［α］27D+18.6°(c=4.86,乙醇中)，［α］２５Ｄ-25.5°(乙酸乙酯中)。最大吸收波长278nm(Ｅ１％1cm298)。
用 途:生化研究。组织培养基。医药
Simga相关产品资料
Sigma C0378 Chloramphenicol
≥98% (TLC)
Synonym: Chloromycetin®, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
CAS Number: 56-75-7
Linear Formula: Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Molecular Weight: 323.13
Beilstein Registry Number: 2225532
EC Number: 200-287-4
MDL number: MFCD00078159
PubChem Substance ID: 24892250
Description
Biochem/physiol Actions Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.
Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
Legal Information Chloromycetin is a registered trademark of Parke-Davis & Co.
Properties
assay ≥98% (TLC)
mp 148-150 °C(lit.)
Gene Information human ... CYP1A2(1544) |