产品信息 Form Dark purple solid Protect from Light 是的 Packaged under inert gas 是的 Purity ≥90% by HPLC (sum of two isomers) Chemical formula C17H13N3O7 • 3H2O Storage -20°C A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
