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产品信息
CAS number 668467-91-2
Storage +2°C to +8°C
Form Orange solid
Primary Target UCH-L1
Primary Target IC50 0.88 µM
Protect from Light 是的
Packaged under inert gas 是的
Reversible 是的
Purity ≥95% by HPLC
Chemical formula C17H11Cl3N2O3
An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type. |