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SHP1/2 PTPase Inhibitor, NSC-87877
8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
产品信息
Form Redish brown solid
Molar mass 503.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility H2O
Chemical formula C19H11N3Na2O7S2
CAS number 56932-43-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |