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产品说明
A cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβtotal IC50 = 17 nM, Aβ40 IC50 = 48 nM, and Aβ42 IC50 = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
产品信息
Form Liquid
Formulation A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
Primary Target Aβtotal
Primary Target IC50 17 nM
Secondary target Aβ40 IC50 = 48 nM, and Aβ42 IC50 = 67 nM in SHSY5Y cells overexpressing spβA4CTF
Protect from Light 是的
Protect from Moisture 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥90% by HPLC
Chemical formula C39H52N4O6
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |