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INSOLUTION G-SECRETASE INHIBITOR X|正品进口

产品编号: 565771-250UG     查看说明书
产品名称: INSOLUTION G-SECRETASE INHIBITOR X|正品进口  .0   订购此产品 
供应商: Merck
规格: 250UG
目录价: 3615
库存状态: 3周到货
CAS编号:
应用范围: 生化实验
种属来源:
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产品说明
A cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβtotal IC50 = 17 nM, Aβ40 IC50 = 48 nM, and Aβ42 IC50 = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
产品信息 
Form  Liquid 
Formulation  A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO. 
Primary Target  Aβtotal 
Primary Target IC50  17 nM 
Secondary target  Aβ40 IC50 = 48 nM, and Aβ42 IC50 = 67 nM in SHSY5Y cells overexpressing spβA4CTF 
Protect from Light  是的 
Protect from Moisture  是的 
Packaged under inert gas  是的 
Cell permeable  是的 
Purity  ≥90% by HPLC 
Chemical formula  C39H52N4O6 
Storage  -20°C 
Ship  Ambient Temperature Only
Standard Handling 

保存条件: -20°C
说明书地址: 点击查看详细
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