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InSolution™ Ro-31-8220
3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate
Form Clear orange-brown liquid
Formulation A 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H2O.
Primary Target PKC
Primary Target IC50 10 nM
Secondary target CaM kinase II (IC50 = 17 µM) and protein kinase A (IC50 = 900 nM). Potently inhibits GSK-3 in primary adipocytes (IC50 = 6.8 nM) and in GSK-3b immunoprecipitates (IC50 = 2.8 nM). An inhibitor of MAP kinase phosphatase-1 expression and an activator of JNK1. Inhibits the phosphorylation of Raf-1 and induces apoptosis, independent of its effects on PKC, in HL-60 cells.
Molar mass 553.7
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C25H23N5O2S • CH3SO3H
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Standard Handling |