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PKG, Iα, Bovine Lung
cGMP-Dependent Protein Kinase Catalytic Subunit, PKGIα Catalytic Subunit, Protein Kinase G Iα
Native PKGIα purified from bovine lung. PKG is involved in regulation of smooth muscle relaxation, platelet function, and cell division. PKG is activated by binding of cGMP to regulatory subunits within the holoenzyme, but in contrast to PKA, the activation of PKG does not invlove physical dissociation of catalytic from the regulatory domains. The activated enzyme phosphorylates target proteins at serine and/or threonine residues that are found within the recognition motif, Arg-Lys-Arg-Ser*-Arg-Ala-Glu. Note: 4µg = 6000 units.
产品信息
Form Liquid
Formulation In 150 mM NaCl, 25 mM β-mercaptoethanol, 10 mM K2HPO4, 1 mM EDTA, 12% sucrose, pH 6.8.
Molar mass 78000
Avoid freeze/thaw 是的
Specific activity ≥1300 units/µg enzyme
Unit definition One unit is defined as the amount of enzyme required to incorporote 1 pmol phosphate into the synthetic heptapeptide substrate, RKRSRAE, in 1 min at 30°C.
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |