|
PP2
AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available.
产品信息
Form Off-white solid
Primary Target p56lck
Primary Target IC50 4 nM
Secondary target p59fynT (IC50 = 5 nM), and Hck (IC50 = 5 nM). anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM)
Molar mass 301.8
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C15H16ClN5
CAS number 172889-27-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |