PERTUSSIS TOXIN, A PROTOMER, B PERTUSSIS

Pertussis Toxin, B Oligomer, Bordetella pertussis
The pentameric cell-binding component that is responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A protomer into receptive cells. Reported to elicit direct cellular responses by binding to several cell surface receptors with oligosaccharide side chains. Also elicits a variety of physiological responses, such as mitogenesis in human T cells, enhancement of aggregation of human platelets, elevation of cytosolic Ca2+ levels, and neutralization of antibody response in mice. Reported to deactivate CCR5 and inhibit the entry of R5 HIV-1 in activated T lymphocytes. Also blocks post-entry step of HIV-1 replication.
产品信息
Form  Lyophilized
Purity  Four distinct bands by SDS-PAGE
Contaminants  ≤1% holotoxin by CHO cell assay
Solubility  H2O or Aqueous Buffers
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Toxic