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PD 158780
4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine
A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC50 = 8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH 3T3 cells. A 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513036) in DMSO is also available.
产品信息
Form Yellow solid
Primary Target EGFR
Primary Target IC50 8 pM
Molar mass 330.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C14H12BrN5
CAS number 171179-06-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |