PTEN, HIS*TAG AND S*TAG, HUMAN REC., SP.

PTEN, His•Tag® and S•Tag™, Human Recombinant, S. frugiperda
Phosphatase and Tensin Homolog Deleted on Chromosome 10
Full-length, recombinant, human PTEN (GenBank target symbol = PTEN, ACC No. BC_005821) fused at N-terminus to a His•Tag® and S•Tag™ sequences and expressed in S. frugiperda insect cells. PTEN is a tumor suppressor that is frequently found mutated in human cancers. It serves as a lipid phosphatase and negative regulator of the PI-3K/Akt pathway. Absence of functional PTEN results in constitutive activation of Akt and mTOR kinases.
产品信息
Form  Liquid
Formulation  In 150 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 1 mM EDTA, 50% glycerol, pH 7.5.
Molar mass  53000
Specific activity  ≥75 U/mg protein
Unit definition  One unit is defined as the amount of enzyme required to liberate 1 nmol phosphate from PIP3 per min at 37°C.
Purity  ≥80% by SDS-PAGE
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Standard Handling