NEURONAL DIFFERENTIATION INDUCER III

Neuronal Differentiation Inducer III
N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
产品信息
Form  Off-white solid
Molar mass  234.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C11H10N2O2S
CAS number  832115-62-5
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling