NFAT Activation Inhibitor III Inhibitor of NFAT-Calcineurin Association-6, INCA-6 A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. 产品信息 Form Yellow solid Primary Target Calcineurin-NFAT Primary Target Ki Kd = 800 nM Molar mass 284.3 Protect from Light 是的 Cell permeable 是的 Purity ≥95% by HPLC Solubility DMSO or EtOH Chemical formula C20H12O2 CAS number 3519-82-2 商店和运输信息 Storage +2°C to +8°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Carcinogenic / Teratogenic