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Naltrindole, Hydrochloride
This product has been discontinued.
A cell-permeable, δ-selective opioid receptor antagonist (Ki = 0.031, 3.8, and 332.7 nM for δ, µ, and κ, respectively) and an inhibitor of cellular Akt signaling. Decreases the cellular phosphorylation level of PDK1, Akt, FKHR/AFX, GSK-3β, and inhibits Akt-dependent cell growth in small cell lung cancer (SCLC) cell lines (IC50 = 25, 40, and 55 µM in NCI-H69, NCI-H345, and NCI-H510, respectively).
产品信息
Form White solid
Primary Target NCI-H69
Primary Target IC50 25 µM
Secondary target IC50 = 40, and 55 µM in NCI-H345, and NCI-H510, respectively
Molar mass 451.0
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility H2O or MeOH
Chemical formula C26H26N2O3 • HCl
CAS number 111469-81-9
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |