在线咨询:点击这里给我发消息   点击这里给我发消息
产品检索
品名:
货号:
品牌:
 
产品分类
  您现在的位置:产品中心 >> 分子生化试剂 >> 生化试剂

MTOR INHIBITOR III, PP242

产品编号: 475988-5MG     查看说明书
产品名称: MTOR INHIBITOR III, PP242  .0   订购此产品 
供应商: Merck
规格: ***
目录价: 1,591.00
库存状态: 3周到货
CAS编号:
应用范围: 生化实验
种属来源:
相关信息:

mTOR Inhibitor III, PP242
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, Dihydrate, TORKinib, mTOR Inhibitor III, PP242
A cell-permeable pyrazolopyrimidine compound that acts as a potent, reversible, and ATP-competitive inhibitor against both mTORC1 & mTORC2 (IC50 = 30 & 58 nM, respectively, with 100 µM ATP). PP242 inhibits PKCα, p110γ, and JAK2 with 6-, 13-, and 14-fold less potency and exhibits much reduced or no activity against a panel of 216 other kinases at a concentration of 1 µM (maximum of 68% or 77% inhibition observed with 10 or 100 µM ATP, respectively). PP242 differentially inhibits insulin-stimulated phosphorylations of cellular proteins both in cultures (2.5 µM) in vitro and in mice (20 mg/kg i.p.) in vivo in a manner distinctly different from that seen in mTORC2-functional knockout SIN1-/- cells or in cultures treated with Rapamycin (Cat. Nos. 553210, 553211, 553212), which targets only mTORC1, but not mTORC2. Blockage of 4EBP1 T36/T45/S65 phosphorylation by PP242 upon insulin stimulation in primary MEFs correlates well with an enhanced 4EBP1 association with the cap-binding protein eIF4E, resulting in a selective inhibition of cap-dependent, but not cap-independent, protein translation.
产品信息
Form  Off-white solid
Molar mass  344.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO
Chemical formula  C16H16N6O • 2H2O
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling

保存条件: -20°C
说明书地址: 点击查看详细
打印此页      关闭此页

上一个:MTOR, HUMAN, RECOMBINANT, S. FRUGIPERDA[475987-10UG/***]
下一个:MTT[475989-10GM/***]
电话:15821622703 15121098156 座机:021-54046790邮箱:sales@haoranbio.com info@haoranbio.com 地址:上海浩然生物(上海浩洋生物科技有限公司) QQ:470003480
 Copyright © 2009上海浩然生物(上海浩洋生物科技有限公司) All Rights Reserved. 网站备案:沪ICP备11023319号-1