|
Met Kinase Inhibitor
(3Z)N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, SU11274
A cell-permeable pyrrole indolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Met kinase activity (IC50 = 20 nM). Exhibits > 60-fold selectivity over Flk and > 400-fold selectivity over Ron, FGFR-1, c-Src, Cdk2, PDGFRβ, EGFR, and Tie-2. Shown to inhibit HGF/SF-stimulated cellular signaling and Met-mediated tumorigenesis in various cancer cell lines.
产品信息
Form Orange solid
Primary Target met kinase activity
Primary Target IC50 20 nM
Molar mass 568.1
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
ATP Competitive 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C28H30ClN5O4S
CAS number 658084-23-2
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant |