MGLUR5 LIGAND, CDPPB

 mGluR5 Ligand, CDPPB
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
A pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
产品信息
Form  Off-white solid
Molar mass  364.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C23H16N4O
CAS number  781652-57-1
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling