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MEK Inhibitor VIII
N-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
A cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
产品信息
Form White solid
Molar mass 476.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C18H16F3IN2O2
CAS number 212631-61-3
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |