MEK Inhibitor I A cell-permeable pyridine-containing vinylogous cyanamide compound that acts as a potent and selective inhibitor of MEK (IC50 = 12 nM) with little activity towards MKK3 and MKK4 (IC50 > 1 µM). The inhibition is noncompetitive with respect to ERK and the compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP). Exhibits superior potency, solubility, and stability compared to U0126 (Cat. No. 662005) in aqueous solutions. Shown to protect against phorbol ester-mediated ear edema in mice (ED50 of 5 mg/kg, ip.). 产品信息 Form White solid Primary Target MEK Primary Target IC50 12 nM Secondary target MKK3 and MKK4 (IC50 > 1 µM) Molar mass 374.5 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥ 95% by HPLC (sum of two isomers) Solubility DMSO or MeOH Chemical formula C21H18N4OS CAS number 297744-42-4 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Standard Handling