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MMP Substrate III, Fluorogenic
A specific fluorogenic resonance energy transfer (FRET) peptide substrate with an MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencher combination. Useful for the detection of MMP activity [kcat/Km = 619,000 M-1s-1 for MMP-2, 206,000 M-1s-1 for MMP-9, 40,000 M-1s-1 for MMP-3, and 21,000 M-1s-1 for MMP-1; at 37°C, pH 7.6 ]. Exhibits a high degree of sensitivity that is not affected by optical disturbances in biological media. Also useful for MMP activity measurements in synovial fluid and culture medium.
产品信息
Peptide Sequence DABCYL-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
Form Red lyophilized solid
Formulation Supplied as a trifluoroacetate salt.
Molar mass 1325.6
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Excitation max. ~340 nm
Emission max. ~485 nm
Solubility DMSO
Chemical formula C63H88N16O14S
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |