Hydroxyfasudil A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo. 产品信息 Form Liquid Formulation A 10 mM (2 mg/582 µl) solution in H2O. Primary Target Rho-kinase Primary Target IC50 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively Molar mass 343.8 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 ATP Competitive 是的 Purity ≥98% by HPLC Chemical formula C14H17N3O3S • HCl CAS number 155558-32-0 商店和运输信息 Storage -20°C Ship Blue Ice Only Harmful
