GRANZYME A, HUMAN, RECOMBINANT, E. COLI

Granzyme A, Human, Recombinant, E. coli
Recombinant, human granzyme A expressed in E. coli. Granzyme A is a trypsin-like serine protease secreted by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. A proapoptotic enzyme that induces cell death through caspase-independent mechanism, causing single-stranded DNA nicking and other apoptotic features including nuclear fragmentation, chromatin condensation, loss of mitochondrial potential, and membrane blebbing. Granzyme A is also known to bind to and cleave nucleolin and activate the thrombin receptor on neuronal cells and astrocytes. It also cleaves and activates interleukin-1β. Note: The M.W. is that of a homodimer.
产品信息
Form  Liquid
Formulation  In 520 mM NaCl, 50 mM MES, 10% glycerol, pH 6.0.
Molar mass  51632
Avoid freeze/thaw  是的
Specific activity  ≥100 units/µg protein
Unit definition  One unit is defined as the amount of enzyme that hydrolyzes 1 nmol Z-Lys-SBzl per min 25°C, pH 8.0.
EC number  3.4.21.78
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Standard Handling