GSK-3β Inhibitor XVIII 2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone A cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC50 = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC50 = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC50 = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells. 产品信息 Form White solid Molar mass 413.9 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C20H20ClN5OS CAS number 1139875-74-3 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling
