GLUCOCORTICOID RECEPTOR MODULATOR, CPDA

Glucocorticoid Receptor Modulator, CpdA
2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
产品信息
Form  White solid
Molar mass  264.2
Protect from Moisture  是的
Purity  ≥97% by HPLC
Solubility  DMSO, EtOH, or H2O
Chemical formula  C11H14ClNO2 • HCl
CAS number  14593-25-0
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Standard Handling