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ω-Conotoxin GVIA, Conus geographus
A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
产品信息
Peptide Sequence H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys8-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹5-Cys¹6-Arg-Ser-Cys¹9-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys26-Tyr-NH2 (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
Form Lyophilized
Molar mass 3037.4
Purity ≥98% by HPLC
Solubility Aqueous Buffers or H2O
Chemical formula C120H182N38O43S6
CAS number 106375-28-4
Declaration Not available for sale outside of the United States.
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Ship Ambient Temperature Only
Highly Toxic
End use certificate To purchase this product, the completion of a "Select Agent Declaration" and/or "End-Use Certificate" is required. Once your sales order is placed, our Regulatory Specialist will be contacting the end-user of this product to complete the required form(s). Please ensure to provide the customer service representative with the end-user's name, telephone number, fax number and e-mail address to prevent delivery delays. (Note: the completed form must be returned within five (5) business days from receipt and will be valid for one year from the date of signing.)
安全标示
S Phrase S: 45-36/37/39
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Wear suitable protective clothing, gloves and eye/face protection.
R Phrase R: 26/27/28
Very toxic by inhalation, in contact with skin and if swallowed. |