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Flt-3 Inhibitor III
A cell-permeable 5-phenyl-2-thiazolamine compound that acts as a potent, ATP binding site-targeting inhibitor of Flt3 (IC50 = 50 nM). It inhibits c-Kit, KDR, c-Abl, Cdk1, c-Src, and Tie-2 only at much higher concentrations (IC50 = 0.26, 0.91, 1.2, 2.1, 2.8, and 8.0 µM, respectively) and exhibits little activity against a panel of 12 other commonly studied kinases even at concentrations as high as 10 µM. Blocks FLT3-dependent cell proliferation in a dose-dependent manner (IC50 = 52, 240, and 760 nM in MV4:11-ITD, BaF3-ITD, and BaF3-D835/Y cells).
产品信息
Form Off-white solid
Molar mass 365.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C21H23N3OS
CAS number 852045-46-6
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Harmful
安全标示
S Phrase S: 26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves.
R Phrase R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed. |