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FGF Receptor Tyrosine Kinase Inhibitor IV, NP603
A cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
产品信息
Form Orange solid
Molar mass 446.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C26H26N2O5
CAS number 949164-80-1
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful
安全标示
S Phrase S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase R: 22-36/37/38
Harmful if swallowed.
Irritating to eyes, respiratory system and skin. |