Fibroblast Growth Factor-2 Inhibitor, NSC37204

Fibroblast Growth Factor-2 Inhibitor, NSC37204
A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).
产品信息
Form  Brown solid
Molar mass  548.45
Purity  >95% by HPLC
Solubility  DMSO
Chemical formula  C21H14N2Na2O9S2
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling