Echinomycin Streptomyces sp. A cell-permeable Streptomyces-derived antibiotic that contains two bicyclic peptide-linked quinoxalines and acts as a sequence-specific DNA bisintercalator. Echinomycin at 10 µM is shown to inhibit HIF-1 and Myc/Max DNA binding activities in U251 and MCF-7 nuclear extracts by >90%, while exhibiting little effect against the binding of AP-1 or NF-κB to their respective DNA targets that lack the 5'-ACGTG-3' core structure in cell-free EMSA assays. Reversibly inhibits hypoxia-induced HIF-1 transcription activity in an HRE promoter-based reporter assay in U215 cells (EC50 = 1.2 nM) and is of no effect against SV40 promoter-driven transcription activity. Despite echinomycin's in vitro apoptosis-inducing activity and the initial report of its in vivo antitumor effect in mice, clinical trials have not yet resulted in promising data regarding its therapeutic efficacy in cancer treatment. 产品信息 Form White solid Molar mass 1101.3 Purity ≥98% by HPLC Solubility DMSO Chemical formula C51H64N12O12S2 CAS number 512-64-1 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Toxic 安全标示 S Phrase S: 36-36/37/39-45-53 Wear suitable protective clothing. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use. R Phrase R: 23/24/25-46 Toxic by inhalation, in contact with skin and if swallowed. May cause heritable genetic damage.