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Damnacanthal
3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
产品信息
Form Orange-yellow solid
Primary Target p56lck autophosphorylation
Primary Target IC50 17 nM
Secondary target p56lck phosphorylation of exogenous peptide
Molar mass 282.3
Protect from Light 是的
Packaged under inert gas 是的
Reversible 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C16H10O5
CAS number 477-84-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |