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Cyclosporin A, Tolypocladium inflatum
Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells.
产品信息
Form White to off-white solid
Primary Target NOS induced by interlukin-1-α
Molar mass 1202.6
Purity ≥97% (dry basis)
Solubility DMSO, EtOH, or MeOH
Chemical formula C62H111N11O12
RTECS GZ4120000
CAS number 59865-13-3
Merck USA index 14, 2752
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic
安全标示
S Phrase S: 22-24/25-36/37
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing and gloves.
R Phrase R: 40
Limited evidence of a carcinogenic effect. |