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Cycloheximide, High Purity
Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions.
产品信息
Form White solid
Primary Target hFKBP12
Primary Target Ki 3.4 µM
Molar mass 281.3
Purity ≥98% by HPLC
Solubility EtOH or MeOH
Chemical formula C15H23NO4
RTECS MA4375000
CAS number 66-81-9
Merck USA index 14, 2728
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Ship Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic
安全标示
S Phrase S: 45-53-61
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Avoid release to the environment. Refer to special instructions/safety data sheet.
R Phrase R: 28-40-51/53-61
Very toxic if swallowed.
Limited evidence of a carcinogenic effect.
Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
May cause harm to the unborn child. |