Cucurbitacin I, Cucumis sativus L. A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK. 产品信息 Form White solid Primary Target JAK/STAT3 Primary Target IC50 500 nM Molar mass 514.7 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Solubility DMSO or EtOH Chemical formula C30H42O7 RTECS RC6200000 CAS number 2222-07-3 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling