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PD 153035
AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
产品信息
Form White solid
Primary Target EGFR
Primary Target IC50 25 pM
Primary Target Ki 6 pM
Molar mass 360.2
Protect from Light 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C16H14BrN3O2
CAS number 153436-54-5
Declaration Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |