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Cathepsin D, Human Liver
Native cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
产品信息
Form Lyophilized
Formulation Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Molar mass 42000
Specific activity ≥300 units/mg protein
Unit definition One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
Purity ≥90% by SDS-PAGE
Source Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Solubility Sterile H2O or Aqueous Buffers
EC number 3.4.23.5
CAS number 9025-26-7
Merck USA index 14, 1905
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |