CALYCULIN A, DISCODERMIA CALYX

Calyculin A, Discodermia calyx
A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Also available as a 100 µM solution in DMSO (Cat. No. 508226).
产品信息
Form  Clear film to white crystalline powder
Primary Target  PP2A
Primary Target IC50  0.5-1 nM
Secondary target  PP1 (IC50 = 2 nM)
Molar mass  1009.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Cell permeable  是的
Purity  ≥98% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C50H81N4O15P
CAS number  101932-71-2
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage  -20°C
Ship  Ambient Temperature Only
Toxic
安全标示
S Phrase  S: 26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase  R: 23/24/25-38
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to skin.