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Calpain Inhibitor XI
A cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
产品信息
Peptide Sequence Z-Leu-Abu-CONH(CH2)3-morpholine (Abu = α-aminobutyric acid)
Form White to off-white solid
Formulation Supplied as a trifluoroacetate salt.
Primary Target calpain 1, calpain 2
Primary Target Ki 140 nM, 41 nM
Secondary target cathepsin B Ki = 6.9 µM
Molar mass 504.6
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C26H40N4O6
CAS number 145731-49-3
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |