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产品信息
Peptide Sequence N-Acetyl-Leu-Leu-Met
Form Off-white solid
Primary Target calpain-1
Primary Target Ki 120 nM
Secondary target calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM)
Cell permeable 是的
Purity >95% by HPLC
Chemical formula C19H35N3O4S
CAS number 110115-07-6
Storage +2°C to +8°C
Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome. |