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Complement C3b, Human
Native, human C3b complement component. Cleavage of the C3-α chain at peptide bond 77 by either of the complement C3 convertase enzymes results in production of C3a (M.W. 9083) and C3b (M.W. 180,000) fragments. The C3b fragment is a glycoprotein composed of the modified C3-α chain (α′) (M.W. 105,000) and the intact C3-β chain (M.W. 75,000). Nascent C3b has the transient ability to form a covalent ester bond with a variety of target surfaces. Once bound to target surfaces C3b becomes an essential subunit of both the classical and alternative pathway C5 cleaving enzymes. In addition, surface-bound C3b has opsonic and immune adherence activities which are mediated via binding to CR1 (CD35) complement receptors.
产品信息
Form Liquid
Formulation In PBS, pH 7.2, filtered through a 0.22 µm filter.
Molar mass 180000
Avoid freeze/thaw 是的
Purity ≥90% by SDS-PAGE
Contaminants IgG, IgA, IgM, C5, Factor H, or Factor I: ≤trace amounts
Source Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |