Apoptosis Inhibitor II, NS3694 A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases. 产品信息 Form White solid Primary Target completely blocks TNF-α-induced death in MCF-casp3 cells Primary Target IC50 50 µM Molar mass 358.7 Protect from Light 是的 Cell permeable 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C15H10ClF3N2O3 CAS number 426834-38-0 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling