Allopregnanolone Allopregnan-3α-ol-20-one, 3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP A natural metabolite of progesterone that is devoid of any progestational activity. Acts as a potent ligand of GABA type A receptor complexes in the CNS. Potentiates the GABA receptor-mediated chloride uptake in synaptosomes 100- to 1,000-fold more effectively than benzodiazepines or barbiturates. Causes a rapid increase in Ca2+ influx in a dose-dependent manner (EC50 =10 nM in fetal hypothalamic neurons). 产品信息 Form White solid Molar mass 318.5 Purity ≥95% by HPLC Solubility DMSO or EtOH Chemical formula C21H34O2 RTECS TU4383000 CAS number 516-54-1 Merck USA index 14, 275 商店和运输信息 Storage +15°C to +30°C Ship Ambient Temperature Only Standard Handling