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ALDH2 Agonist, Alda-1
N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
A cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
产品信息
Form Off-white solid
Molar mass 324.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility EtOH
Chemical formula C15H11Cl2NO3
CAS number 349438-38-6
Declaration Patent pending.
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |