ALENDRONATE, SODIUM SALT

Alendronate, Sodium Salt
Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
产品信息
Form  White solid
Molar mass  325.1
Hygrocopic  是的
Purity  ≥98% by titration
Solubility  H2O
Chemical formula  C4H12NNaO7P2 • 3H2O
RTECS  SZ6523500
CAS number  121268-17-5
Merck USA index 14, 229
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Harmful