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FAK [pY397] Polyclonal Antibody, Rabbit
This purified Rabbit FAK [pY397] polyclonal antibody recognizes FAK that is phosphorylated at tyrosine 397. Focal Adhesion Kinase plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase of the cell cycle. Rabbit FAK [pY397] polyclonal antibody has been validated for use in western blot applications. Previous lots of FAK [pY397] polyclonal antibody have been validated for use in immunocytochemistry and immunohistochemistry.
Antibody Specifications:
• Applications: The validated application for Rabbit FAK [pY397] Polyclonal Antibody is western blotting.
• Host Species and Isotype: The host species and isotype of the FAK polyclonal antibody is Rabbit IgG.
• Reactivity: Detects human, mouse, rat, frog, and fly FAK.
• Product Size: Rabbit anti-FAK [pY397] Polyclonal Antibody is available in a 10 mini-blot size.
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and is involved in its initial activation. This phosphorylated site binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion.
Reactivity: Mouse,
Drosophila,
Chicken,
Human,
Xenopus
Validated Application: Western Blot,
Immunohistochemistry
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: FAK [pY397]
Gene ID: 5747
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 10 blots
Protein Family: Extracellular Matrix Proteins,
Kinases & Inhibitors
Research Category: Extracellular Matrix & Cell Adhesion,
Signal Transduction
Other Additives: Sodium Azide Preservative
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |