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RB [pS780] Rabbit Polyclonal Antibody
Rb is a 120 kDa tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F-1, PU.1, ATF-2, UBF, Elf-1 and c-abl. This ability to alter transcription is regulated by phosphorylation catalyzed by the cyclin-dependent protein kinases (cdks). Phosphorylation of serine 780 is catalyzed by cdk complexes such as Cyclin D1-cdk4. Rb contains at least 16 consensus sequences for cdk phosphorylation, but the significance of all of these sites is unclear. Phosphorylation of serines 612, 780, 807, and 811 disrupts binding to E2F.
Format:
Unconjugated
Application:
WB
Reactivity: Human
Validated Application: Western Blot
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: RB [pS780]
Gene ID: 5925
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 10 blots
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-20°C). |