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MEK4 [pSpT257/261] Rabbit Polyclonal Antibody
Mitogen-Activated Protein Kinase Kinase 4 (MEK4 or MKK4) is a 42 kDa member of a tyrosine⁄threonine protein kinase family that activates the c-Jun NH2-terminal kinases (JNK), which is part of the inflammation⁄stress signaling pathway. The mutation of the MEK4 gene in some carcinomas indicates that it may also have a role as a tumor suppressor. Phosphorylation of MEK4 by MEKK1 on serine 257 and threonine 261 in the catalytic domain activates the protein and enables MEK4 to phosphorylate JNK.
Rabbit (polyclonal) Anti-MEK4 [pSpT257⁄261] Phosphospecific Antibody, Unconjugated is reactive to human MEK4 and is validated in Western Blot. Mouse and frog (100% homologous) MEK4 have not been tested, but are expected to react. Mek4 is also known as MAP2K4, mitogen-activated protein kinase kinase 4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1, JNK activating kinase 1; JNK-activated kinase 1; MAP kinase kinase 4; MAPK⁄ERK kinase 4; SAPK⁄ERK kinase 1; c-Jun N-terminal kinase kinase 1.
Catalog number 44474G is the same antibody as former catalog number 44474. 44474G contains 50% glycerol, which improves the stability and longevity of this antibody.
Reactivity: Human
Validated Application: Western Blot
Host: Rabbit
SubClass (Isotype): Multi
Clonality: Polyclonal
Clone ID: pAB Rb(IgG)
Antibody Fragment: Whole Antibody
Target Gene: MEK4 [pSpT257/261]
Target Molecule: Proteins (Phosphoproteins)
Gene ID: 6416
Gene Symbol: MAP2K4
Label or Dye: Unconjugated
Target Modification State: Phospho
Purification: Affinity Purified
Color: None
Form: Frozen
Platform: iBlot®
Product Size: 10 blots
Protein Family: Kinases & Inhibitors
Quantity: 10 blots
Volume: 100 µl
Research Category: Signal Transduction
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
10 blots (100µL)
Store at -20°C for shipment or short-term storage (up to one week), 2-8°C is sufficient. |